Bufadienolides. III. Reduction of Resibufogenin with Sodium Borohydride
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چکیده
منابع مشابه
The reduction of cozymase by sodium borohydride.
Cozymase (diphosphopyridine nucleotide, DPN) has been assayed by a variety of biochemical and chemical methods (1). Among the simplest procedures has been the determination of the light absorption of reduced DPN at 340 rnp after reduction by sodium hydrosulfite. Since special precautions are required to remove completely the excess reducing agent which absorbs in this region, it appeared advant...
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Sodium borohydride is a well known reducing agent. In methanol at room temperature formyl and keto groups are readily reduced to alcohol groups, while ester and carboxyl groups, carbon-carbon and carbon-nitrogen double bonds are only reduced with difficulty (2, 17). Of the groups present in chlorophyll b the C3 formyl and the C9 keto groups should be amenable to reduction, while the C2 vinyl an...
متن کاملInactivation of Tetracycline with Sodium Borohydride.
Recently we reported on the rapid inactivation of tetracycline by use of cupric-morpholine complex (Kaplan, Lannon, and Buckwalter, J. Pharm. Sci., 64, 163, 1965). This degradation procedure is used as part of an assay technique for kanamycin in the presence of tetracycline. We have since found that sodium borohydride (Metal Hydrides Inc., Beverly, Mass.) can substitute for cupric-morpholine co...
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Reduction of oxi me fu nctionality to amine is an important synthetic transformation . As ox imes are stable derivatives of carbonyl compounds, subsequent reduction to amines is an attractive two-step procedure for reductive ami nation . Red uction of oximes to amines can be performed by hydride reducing agents or by catalytic hydrogenation.' Among hydride reducing agents, lithium aluminium hyd...
متن کاملSelective Reduction of Cytochrome C Oxidase with Borohydride.
Since the pioneer studies of Keilin and Hartree (l), considerable evidence has accumulated indicating that cytochrome c oxidase contains two heme moieties that react differently; hence the designation cytochrome U-Q. Reasons for this designat.ion include kinetic studies that show (a) differences in the rate of reduction and oxidation of cytochrome c oxidase measured at the a versus y absorption...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1969
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.17.1246